Pangu BioPharma (an aTyr Pharma Subsidiary) and The Hong Kong University of Science and Technology Recognized for Pioneering Work Leading to New Investigational Therapeutic for Lung Disease
Significant opportunity to replicate collaborative model to develop pipeline of extracellular tRNA synthetase therapeutics
SAN DIEGO and HONG KONG,
Dr. Sanjay Shukla, President, Chief Executive Officer and Director of aTyr, said, “We are advancing our lead candidate ATYR1923 through clinical development in patients suffering from pulmonary sarcoidosis, a rare form of fibrotic lung disease with no known cure and of growing importance worldwide, including China. We are grateful to HKUST researchers for essential collaborative efforts that made this important milestone possible.”
HKUST researchers with support from Pangu were instrumental in discovering a splice variant of histidyl-tRNA synthetase (HARS) that liberates the smaller, active immuno-modulatory (iMod) domain from the full-length tRNA synthetase and has been shown to modulate the immune system. ATYR1923 is a fusion protein comprised of the iMod domain fused to the FC region of a human antibody. To date, researchers at HKUST have discovered over 200 novel compositions that are covered in issued patents and have published six articles detailing their research in peer-reviewed scientific journals.
Prof. Mingjie Zhang, Chair Professor of the
Prof. Paul Schimmel, co-founder and director of aTyr Pharma and visiting professor at HKUST’s
aTyr is developing ATYR1923 as a potential therapeutic for patients with interstitial lung diseases. ATYR1923, a fusion protein comprised of the immuno-modulatory domain of histidyl tRNA synthetase (HARS) fused to the FC region of a human antibody, is a selective modulator of Neuropilin-2 that downregulates the innate and adaptive immune response in inflammatory disease states. aTyr initiated a proof-of-concept Phase 1b/2a trial evaluating ATYR1923 in patients with pulmonary sarcoidosis in the fourth quarter of 2018. This Phase 1b/2a study is a multiple-ascending dose, placebo-controlled, first-in-patient study of ATYR1923 that has been designed to evaluate the safety, tolerability, steroid sparing effect, immunogenicity and pharmacokinetics (PK) profile of multiple doses of ATYR1923. For the Phase 1b/2a trial, aTyr is collaborating with the
About Pulmonary Sarcoidosis
Sarcoidosis is an inflammatory disease characterized by the formation of granulomas, clumps of inflammatory cells, in one or more organs in the body. Sarcoidosis affects people of all ages, but typically presents before the age of 50 years, with the incidence peaking at 20 to 39 years. The disorder usually begins in the lungs, skin or lymph nodes, but can affect almost any organ. Sarcoidosis in the lungs is called pulmonary sarcoidosis and 90% or more of patients with sarcoidosis have lung involvement. Pulmonary sarcoidosis is a major form of interstitial lung disease (ILD) a group of immune-mediated disorders which cause progressive fibrosis of lung tissue. Estimates of prevalence vary; however, aTyr believes that approximately 200,000 Americans live with pulmonary sarcoidosis. The prognosis for patients with pulmonary sarcoidosis ranges from benign and self-limiting to chronic, debilitating disease with mortality.
aTyr is a biotherapeutics company engaged in the discovery and development of innovative medicines based on novel immunological pathways. aTyr’s research and development efforts are concentrated on a newly discovered area of biology, the extracellular functionality of tRNA synthetases. aTyr has built a global intellectual property estate directed to a potential pipeline of protein compositions derived from 20 tRNA synthetase genes. aTyr is focused on the therapeutic translation of the Resokine pathway, comprised of extracellular proteins derived from the histidyl tRNA synthetase gene family. ATYR1923 is a clinical-stage product candidate which binds to the neuropilin-2 receptor and is designed to down-regulate immune engagement in interstitial lung diseases and other immune-mediated diseases. For more information, please visit http://www.atyrpharma.com.
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|aTyr Pharma, Inc.||The Hong Kong University of Science and Technology|
|Joyce Allaire||Johnny Tam|
|Managing Director, LifeSci Advisors, LLC||Manager (PR & Media)|
Source: aTyr Pharma, Inc.