Leading Immunobiology Researcher Dr. David Briscoe Joins aTyr Pharma as Scientific Advisor
“We are pleased to have attracted Dr. Briscoe as an advisor to help guide the expansion and development of our earlier stage pipeline based on NRP2 biology,” said Dr.
“Having recently participated in aTyr’s inaugural summit meeting on NRP2 biology in April, it is clear that there is a rapidly growing body of evidence to suggest that NRP2 plays a key role in a broad range of disorders with significant unmet medical needs, including cancer, inflammation and vascular biology,” said Dr. Briscoe. “I look forward to working with the aTyr team to exploit this emerging pathway.”
About Neuropilin-2 (NRP2)
NRP2 is a pleiotropic cell surface receptor that plays a key role in lymphatic development and in regulating inflammatory responses. In many forms of cancer, high NRP2 expression is associated with worse outcomes. NRP2 can interact with multiple ligands and co-receptors to influence their functional roles. aTyr is actively investigating NRP2 receptor biology, both internally and in collaboration with key academic thought leaders, to identify new product candidates for a variety of disease settings, including cancer, inflammation, and lymphangiogenesis.
aTyr is a biotherapeutics company engaged in the discovery and development of innovative medicines based on novel biological pathways. aTyr’s research and development efforts are concentrated on a newly discovered area of biology, the extracellular functionality of tRNA synthetases. aTyr has built a global intellectual property estate directed to a potential pipeline of protein compositions derived from 20 tRNA synthetase genes. aTyr is focused on the therapeutic translation of the Resokine pathway, comprised of extracellular proteins derived from the histidyl tRNA synthetase gene family. ATYR1923 is a clinical-stage product candidate which binds to the neuropilin-2 receptor and is designed to down-regulate immune engagement in interstitial lung diseases and other immune-mediated diseases. For more information, please visit http://www.atyrpharma.com.
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|Managing Director, LifeSci Advisors, LLC|
Source: aTyr Pharma, Inc.