aTyr Pharma to Host Inaugural Summit Meeting on Neuropilin-2 (NRP-2) Biology
“We are pleased to host this inaugural summit meeting which should serve to advance our collective understanding of the emerging role of NRP-2 in modulating immune responses across a broad range of disease states,” said Dr.
The confirmed attendees include:
Diane Bielenberg, Ph.D., Assistant Professor, Vascular Biology Program, Boston Children's Hospital
- Dr. David Briscoe, MB, ChB., Director, Transplant Research Program and Fellowship Program and Professor of Pediatrics,
Harvard Medical School
Kaustubh Datta, Ph.D., Professor, Biochemistry and Molecular Biology, University of Nebraska Medical School
Robert M. Gemmill, Ph.D., Melvyn Berlinsky Chair in Cancer Research, Professor of Medicine, Hematology/Oncology Division Medical University of South Carolina
Arthur Mercurio, Ph.D., Vice Chair and Professor, Molecular, Cell and Cancer Biology, University of Massachusetts Medical School
Michael Muders, Ph.D., Universitätsklinikum Carl Gustav Carus Dresden, Dresden, Saxony, Germany
Craig Vander Kooi, Ph.D., Associate Professor Department of Molecular and Cellular Biochemistry, University of Kentucky
NRP-2 is a cell surface receptor protein that modulates a broad range of cellular functions through its roles as an essential cell surface receptor and co-receptor for a variety of ligands. Although originally identified as an axonal guidance factor during neuronal development, it is increasingly recognized that NRP-2 also plays a key role in normal and pathophysiology. For instance, it functions during epithelial to mesenchymal transition (EMT), by promoting TGF-β1-mediated EMT in colorectal and other cancer cells and by mediating EMT or endo-EMT in fibroblasts, myofibroblasts, and endothelial cells to promote fibrosis formation. NRP-2 also modulates smooth muscle contractility, regulates autophagy, and influences immune cell activation and migration. NRP-2 expression promotes lymphangiogenesis and single nucleotide polymorphisms (SNPs) in NRP-2 are associated with lymphedema. Neuropilins also act as multifunctional co-receptors which are involved in tumor initiation, growth, metastasis and immunity.
aTyr is developing ATYR1923 as a potential therapeutic for patients with interstitial lung diseases. ATYR1923, a fusion protein comprised of the immuno-modulatory domain of histidyl tRNA synthetase fused to the FC region of a human antibody, is a selective modulator of Neuropilin-2 that downregulates the innate and adaptive immune response in inflammatory disease states. aTyr initiated a proof-of-concept Phase 1b/2a trial evaluating ATYR1923 in patients with pulmonary sarcoidosis in the fourth quarter of 2018. This Phase 1b/2a study is a multi-ascending dose, placebo-controlled, first-in-patient study of ATYR1923 that has been designed to evaluate the safety, tolerability, steroid sparing effect, immunogenicity and pharmacokinetics profile of multiple doses of ATYR1923. For the Phase 1b/2a trial, aTyr is collaborating with the Foundation for Sarcoidosis Research (FSR), the nation’s leading nonprofit organization dedicated to finding a cure for sarcoidosis and improving care for sarcoidosis patients. Under the terms of the collaboration, FSR will assist with clinical trial site initiation and patient enrollment.
aTyr is a biotherapeutics company engaged in the discovery and development of innovative medicines based on novel immunological pathways. aTyr’s research and development efforts are concentrated on a newly discovered area of biology, the extracellular functionality of tRNA synthetases. aTyr has built a global intellectual property estate directed to a potential pipeline of protein compositions derived from 20 tRNA synthetase genes. aTyr is focused on the therapeutic translation of the Resokine pathway, comprised of extracellular proteins derived from the histidyl tRNA synthetase gene family. ATYR1923 is a clinical-stage product candidate which binds to the neuropilin-2 receptor and is designed to down-regulate immune engagement in interstitial lung diseases and other immune-mediated diseases. For more information, please visit http://www.atyrpharma.com.
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|Managing Director, LifeSci Advisors, LLC|
Source: aTyr Pharma, Inc.