aTyr Pharma Announces Research Collaboration with the University of Nebraska Medical Center and Expansion of Successful Pilot Study
Collaboration to advance neuropilin-2 biology and explore potential therapeutic opportunities for ATYR1923
Reinforces aTyr’s commitment to working with a strategic network of leading academic collaborators
The collaboration will investigate:
- the role of ATYR1923 on modulating the functional properties of myeloid cells, including macrophage biology;
- the importance of endogenous Resokine:NRP-2 interactions in other functional properties of myeloid cells;
- the involvement of individual NRP-2 co-receptors/ligands on myeloid cell biology; and
- an assessment of the impact of different anti-NRP-2 domain-specific antibodies in immunology and cancer biology.
“We believe the combination of our science and unique reagents and Dr. Datta’s deep insights in NRP-2 biology will yield valuable information that will guide our ongoing translational research programs, and we look forward to a long and mutually beneficial partnership,” said Dr.
aTyr is developing ATYR1923 as a potential therapeutic for patients with interstitial lung diseases. ATYR1923, a fusion protein comprised of the immuno-modulatory domain of histidyl tRNA synthetase (HARS) fused to the FC region of a human antibody, is a selective modulator of neuropilin-2 that downregulates the innate and adaptive immune response in inflammatory disease states. aTyr initiated a proof-of-concept Phase 1b/2a trial evaluating ATYR1923 in patients with pulmonary sarcoidosis in the fourth quarter of 2018. This Phase 1b/2a study is a multiple-ascending dose, placebo-controlled, first-in-patient study of ATYR1923 that has been designed to evaluate the safety, tolerability, steroid sparing effect, immunogenicity and pharmacokinetics (PK) profile of multiple doses of ATYR1923. For the Phase 1b/2a trial, aTyr is collaborating with the
aTyr is a biotherapeutics company engaged in the discovery and development of innovative medicines based on novel immunological pathways. aTyr’s research and development efforts are concentrated on a newly discovered area of biology, the extracellular functionality of tRNA synthetases. aTyr has built a global intellectual property estate directed to a potential pipeline of protein compositions derived from 20 tRNA synthetase genes. aTyr is focused on the therapeutic translation of the Resokine pathway, comprised of extracellular proteins derived from the histidyl tRNA synthetase gene family. ATYR1923 is a clinical-stage product candidate which binds to the neuropilin-2 receptor and is designed to down-regulate immune engagement in interstitial lung diseases and other immune-mediated diseases. For more information, please visit http://www.atyrpharma.com.
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|Managing Director, LifeSci Advisors, LLC|
Source: aTyr Pharma, Inc.