aTyr Pharma Announces Research Collaboration with Boston Children’s Hospital
“This collaboration with Dr. Bielenberg is very consistent with our strategy of partnering with academia in the further exploration of NRP2 and its underlying role in human disease,” said Dr.
Hollow organs, such as the bladder or gastrointestinal (GI) tract, function to expel waste products via the action of smooth muscle contraction. Aberrant pressure, especially in the bladder, can initiate hypertrophy of the bladder wall and lead to inflammation and fibrosis with eventual decompensation in smooth muscle, increased pressure transmitted to the kidneys, and pathological renal damage.
“The ability of NRP2 to promote smooth muscle relaxation, along with its robust expression in hollow organs, implies that this axis could be exploited for therapeutic benefit in conditions characterized by inappropriate smooth muscle contractility,” noted Dr. Bielenberg. “These include bladder conditions, such as urinary incontinence, as well as GI tract motility disorders, such as intestinal pseudo-obstruction and paralytic ileus. Current treatments for such diseases can have significant side effects and limited efficacy, therefore we are eager to explore new therapeutic options with the
Biography: Dr. Bielenberg received a full scholarship to attend the
aTyr is a biotherapeutics company engaged in the discovery and development of innovative medicines based on novel immunological pathways. aTyr’s research and development efforts are concentrated on a newly discovered area of biology, the extracellular functionality of tRNA synthetases. aTyr has built a global intellectual property estate directed to a potential pipeline of protein compositions derived from 20 tRNA synthetase genes. aTyr is focused on the therapeutic translation of the Resokine pathway, comprised of extracellular proteins derived from the histidyl tRNA synthetase gene family. ATYR1923 is a clinical-stage product candidate which binds to the neuropilin-2 receptor and is designed to down-regulate immune engagement in interstitial lung diseases and other immune-mediated diseases. For more information, please visit http://www.atyrpharma.com.
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Source: aTyr Pharma, Inc.