aTyr Pharma Announces Publication in the Journal Cellular and Molecular Immunology
Paper highlights the essential role that histidyl tRNA synthetase (HARS) plays in immune responses in a broad range of inflammatory disease states
Lead therapeutic candidate, ATYR1923, being evaluated in a Phase 1b/2a trial in patients with pulmonary sarcoidosis
In mouse and rodent models of acute inflammatory disease, researchers found that HARS administration was shown to downregulate immune response. In contrast, HARS neutralization through targeting antibodies was associated with the activation of the immune system and the perpetuation of chronic and acute autoimmune diseases, including interstitial lung diseases (ILDs). aTyr’s lead therapeutic candidate, ATYR1923, is currently being evaluated in a Phase 1b/2a clinical trial as a potential treatment for patients with pulmonary sarcoidosis, an ILD characterized by the formation of granulomas, clumps of inflammatory cells in the lungs. The prognosis for patients with pulmonary sarcoidosis ranges from benign and self-limiting to chronic, debilitating disease with mortality.
“These published findings strongly validate our hypothesis that the extracellular functionality of tRNA synthetases, a newly discovered area of biology, may hold the key to slowing or halting the progression of interstitial lung diseases, thereby preserving lung function and improving patient outcomes,” said
aTyr will provide a corporate update during its upcoming fourth quarter financial and operating results conference call.
aTyr is developing ATYR1923 as a potential therapeutic for patients with interstitial lung diseases. ATYR1923, a fusion protein comprised of the immuno-modulatory domain of histidyl tRNA synthetase fused to the FC region of a human antibody, is a selective modulator of neuropilin-2 that downregulates the innate and adaptive immune response in inflammatory disease states. aTyr is currently enrolling a proof-of-concept Phase 1b/2a trial evaluating ATYR1923 in patients with pulmonary sarcoidosis. This Phase 1b/2a study is a multi-ascending dose, placebo-controlled, first-in-patient study of ATYR1923 that has been designed to evaluate the safety, tolerability, steroid sparing effect, immunogenicity and pharmacokinetics profile of multiple doses of ATYR1923.
aTyr is a biotherapeutics company engaged in the discovery and development of innovative medicines based on novel immunological pathways. aTyr’s research and development efforts are concentrated on a newly discovered area of biology, the extracellular functionality and signaling pathways of tRNA synthetases. aTyr has built a global intellectual property estate directed to a potential pipeline of protein compositions derived from 20 tRNA synthetase genes and their extracellular targets. aTyr’s primary focus is ATYR1923, a clinical-stage product candidate which binds to the neuropilin-2 receptor and is designed to down-regulate immune engagement in interstitial lung diseases. For more information, please visit http://www.atyrpharma.com.
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Source: aTyr Pharma, Inc.