75000 - Document - Document and Entity Information
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75010 - Statement - Consolidated Balance Sheets
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75020 - Statement - Consolidated Balance Sheets (Parenthetical)
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75030 - Statement - Consolidated Statements of Operations
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75040 - Statement - Consolidated Statements of Comprehensive Loss
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75050 - Statement - Consolidated Statements of Stockholders' Equity
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75060 - Statement - Consolidated Statements of Cash Flows
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75070 - Statement - Consolidated Statements of Cash Flows 2
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995455 - Disclosure - Cybersecurity Risk Management, Strategy, and Governance
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995465 - Disclosure - Organization, Business and Basis of Presentation
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995475 - Disclosure - Summary of Significant Accounting Policies
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995485 - Disclosure - Fair Value Measurements
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995495 - Disclosure - License and Collaboration Agreements
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995505 - Disclosure - Balance Sheet Details
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995515 - Disclosure - Commitments and Contingencies
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995525 - Disclosure - Stockholders' Equity
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995535 - Disclosure - Income Tax
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995545 - Disclosure - Employee Benefits
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995555 - Disclosure - Summary of Significant Accounting Policies (Policies)
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995565 - Disclosure - Organization, Business and Basis of Presentation (Tables)
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995575 - Disclosure - Summary of Significant Accounting Policies (Tables)
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995585 - Disclosure - Fair Value Measurements (Tables)
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995595 - Disclosure - Balance Sheet Details (Tables)
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995605 - Disclosure - Commitments and Contingencies (Tables)
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995615 - Disclosure - Stockholders' Equity (Tables)
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995625 - Disclosure - Income Tax (Tables)
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995635 - Disclosure - Organization, Business and Basis of Presentation - Additional Information (Detail)
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995645 - Disclosure - Organization, Business and Basis of Presentation - Summary of Significant Expense Categories Reviewed By CODM (Details)
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995655 - Disclosure - Summary of Significant Accounting Policies - Additional Information (Detail)
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995665 - Disclosure - Summary of Significant Accounting Policies - Schedule of Potentially Dilutive Securities Not Included in Calculation of Diluted Net Loss Per Share (Detail)
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995675 - Disclosure - Summary of Significant Accounting Policies - Summary of Net Loss Per Share (Detail)
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995685 - Disclosure - Fair Value Measurements - Schedule of Assets Measured at Fair Value on Recurring Basis (Detail)
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995695 - Disclosure - Fair Value Measurements - Schedule of Available-for-sale Investments (Detail)
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995705 - Disclosure - Fair Value Measurements - Additional Information (Detail)
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995715 - Disclosure - License and Collaboration Agreements - Additional Information (Detail)
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995725 - Disclosure - Balance Sheet Details - Summary of Prepaid Expenses (Detail)
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995735 - Disclosure - Balance Sheet Details - Summary of Property and Equipment (Detail)
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995745 - Disclosure - Balance Sheet Details - Additional Information (Detail)
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995755 - Disclosure - Balance Sheet Details - Summary of Accrued Expenses (Detail)
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995765 - Disclosure - Commitments and Contingencies - Additional Information (Detail)
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995775 - Disclosure - Commitments and Contingencies - Schedule of Future Minimum Payments under Facility Lease and Reconciliation to Operating Lease Liability (Detail)
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995785 - Disclosure - Commitments and Contingencies - Schedule of Future Minimum Payments under Facility Lease and Reconciliation to Operating Lease Liability (Detail) 2
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995795 - Disclosure - Commitments and Contingencies - Schedule of Future Minimum Payments under Financing Lease and Reconciliation to Financing Lease Liability (Detail)
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995805 - Disclosure - Commitments and Contingencies - Schedule of Future Minimum Payments under Financing Lease and Reconciliation to Financing Lease Liability (Detail) 2
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995815 - Disclosure - Stockholders' Equity - Additional Information (Detail)
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995825 - Disclosure - Stockholders' Equity - Summary of Stock Option Activity (Detail)
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995835 - Disclosure - Stockholders' Equity - Summary of Assumptions Used to Determine Fair Value of Employee Stock Option Grants, Employee Stock Purchase Plan and Performance Options with Market Condition (Detail)
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995845 - Disclosure - Stockholders' Equity - Schedule of Restricted Stock Unit Activity (Detail)
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995855 - Disclosure - Stockholders' Equity - Schedule of Allocation of Stock-Based Compensation for All Stock Options and Restricted Stock Units (Detail)
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995865 - Disclosure - Stockholders' Equity - Summary of Warrants Outstanding (Detail)
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995875 - Disclosure - Stockholders' Equity - Summary of Common Stock Reserved for Future Issuance (Detail)
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995885 - Disclosure - Income Tax - Schedule of Pretax Losses for Domestic and Foreign Operations (Detail)
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995895 - Disclosure - Income Tax - Additional Information (Detail)
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995905 - Disclosure - Income Tax - Schedule of Reconciliation of U.S. Federal Statutory Rate to Effective Rate (Detail)
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995915 - Disclosure - Income Taxes - Schedule of Reconciliation of U.S. Federal Statutory Rate to Effective Rate (Parenthetical) (Details)
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995925 - Disclosure - Income Tax - Schedule of Significant Components of Deferred Tax Assets (Detail)
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995935 - Disclosure - Income Tax - Schedule of Activity Related to Unrecognized Tax Benefits (Detail)
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995945 - Disclosure - Employee Benefits - Additional Information (Detail)
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Common Stock, Value, Subscriptions
Agreed upon value of sale of common stock per transaction
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Forfeitures and Expirations in Period, Weighted Average Exercise Price
Weighted Average Exercise Price, Canceled/forfeited/expired
Proceeds from Sale of Property, Plant, and Equipment
Proceeds from sale of property and equipment
Proceeds from Sale of Property, Plant, and Equipment, Total
Warrant two.
Warrant Two [Member]
Warrant Two [Member]
Issuance of common stock upon exercise of options and release of restricted stock units share.
Issuance Of Common Stock Upon Exercise Of Options And Release Of Restricted Stock Units Share
Issuance of common stock upon release of restricted stock units, Shares
Income (Loss) from Continuing Operations before Income Taxes, Foreign
Foreign
Common stock options and restricted stock units.
Common Stock Options And Restricted Stock Units [Member]
Common Stock Options and Restricted Stock Units [Member]
Finance Lease, Liability
Present value of lease payments
Entity Incorporation, State or Country Code
Entity Incorporation, State or Country Code
2027
Finance Lease, Liability, to be Paid, Year Four
Preferred Stock, Shares Issued
Preferred stock, shares issued
Statement of Financial Position Location, Balance [Domain]
Balance Sheet Location
Vice President
Vice President [Member]
Plan Name [Axis]
Plan Name
Research and Development Expense [Abstract]
Research and development expenses:
Debt Securities, Available-for-Sale, Continuous Unrealized Loss Position, 12 Months or Longer
Available-for-sale, investments in unrealized loss positions, greater than twelve months, market value
Equity [Abstract]
Entity Current Reporting Status
Entity Current Reporting Status
U.S. Government Agencies [Member]
US Government Agencies Debt Securities [Member]
Municipal Bonds [Member]
Municipal Bonds [Member]
Operating Expenses [Abstract]
Operating expenses:
Fair Value, Inputs, Level 2 [Member]
Significant Other Observable Inputs (Level 2) [Member]
Deferred Tax Assets, Net of Valuation Allowance
Total deferred tax assets
Commitments and Contingencies Disclosure [Text Block]
Commitments and Contingencies
Common Stock, Shares Authorized
Common stock, shares authorized
Share-Based Payment Arrangement, Tranche Three [Member]
Share-Based Payment Arrangement, Tranche Three
Prepaid clinical and research expense.
Prepaid Clinical And Research Expense [Member]
Prepaid Clinical and Research Expense [Member]
Investment, Policy [Policy Text Block]
Investment Securities
Common Stock Value Subscriptions Sales Made Prior to Amendment
Common stock value subscriptions sales made prior to amendment.
Common stock value subscriptions sales made prior to amendment
Product and Service [Axis]
Product and Service
Document Fiscal Period Focus
Document Fiscal Period Focus
Finance Lease, Liability [Abstract]
Accounting Standards Update 2023-09 [Member]
Revenue from Contract with Customer [Abstract]
Revenues:
Entity Shell Company
Entity Shell Company
Other Accrued Liabilities, Current
Other accrued expenses
Other prepaid expenses.
Other Prepaid Expenses [Member]
Other Prepaid Expenses [Member]
Short-Term Investments [Member]
Short-term Investments
Segment Reporting, Policy [Policy Text Block]
Segment Reporting
Cash and Cash Equivalent
Cash and Cash Equivalents, at Carrying Value, Total
Cash and cash equivalents at the end of period
Cash and cash equivalents
Cybersecurity Risk Management, Strategy, and Governance [Abstract]
Common Stock, Shares, Issued
Common stock, shares issued
Cybersecurity Risk Management Positions or Committees Responsible Report to Board [Flag]
Cybersecurity Risk Board of Directors Oversight [Text Block]
Asset Class [Domain]
Asset Class
Statement [Table]
Statement [Table]
Restricted Cash, Noncurrent
Restricted cash at the end of period
Restricted cash
Unrecognized Tax Benefits, Increase Resulting from Current Period Tax Positions
Increase related to current year tax positions
Right-of-Use Asset Obtained in Exchange for Operating Lease Liability
Right-of-use assets obtained in exchange for lease obligation
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value
Weighted average grant date fair value of options granted
Warrants for common stock.
Warrants For Common Stock [Member]
Common Stock Warrants [Member]
Common Stock Warrants [Member]
Statement [Line Items]
Statement [Line Items]
Proceeds from issuance of common stock from underwritten follow-on public offering, net of offering costs
Proceeds From Issuance Of Common Stock Through Underwritten Follow On Offering Net Of Offering Costs
Proceeds from issuance of common stock through underwritten follow on offering net of offering costs.
Loss contingency, lawsuit filing date
Loss Contingency, Lawsuit Filing Date
Entity Filer Category
Entity Filer Category
Employee retention credit receivable - general and administrative expenses
Employee Retention Credit Receivable General And Administrative Expenses
Employee retention credit receivable general and administrative expenses.
Cash and cash equivalents and restricted cash policy.
Cash And Cash Equivalents and Restricted Cash Policy [Policy Text Block]
Cash and Cash Equivalents and Restricted Cash
Schedule of common stock reserved for future issuance.
Schedule Of Common Stock Reserved For Future Issuance Table [Text Block]
Summary of Common Stock Reserved for Future Issuance
Liabilities and Equity
Total liabilities and stockholders’ equity
Effective Income Tax Rate Reconciliation, Tax Contingency, Percent
Effective Income Tax Rate Reconciliation, Tax Contingency, Percent, Total
Changes in unrecognized tax benefits
Long-Lived Tangible Asset [Axis]
Long-Lived Tangible Asset
Finance Lease, Liability, to be Paid, Year Three
2027
Security deposit of facility lease and financing leases
Security Deposit Of Facility Lease And Financing Leases
Security deposit of facility lease and financing leases.
Cybersecurity Risk Third Party Oversight and Identification Processes [Flag]
License and collaboration agreement revenues
License and Collaboration Revenues.
License and Collaboration Revenues [Member]
Cash and Cash Equivalents, Fair Value Disclosure
Cash equivalents
Efzofitimod Research and Development Expenses
Efzofitimod research and development expenses.
Efzofitimod expenses
Valuation allowance
Valuation allowance
Deferred Tax Assets, Valuation Allowance
Effective Income Tax Rate Reconciliation, at Federal Statutory Income Tax Rate, Percent
Expected income taxes benefit at federal statutory rate, Percent
U.S. federal statutory tax rate
Shares Issued, Price Per Share
Shares Issued, Price Per Share
Shares issued, price per share
Cybersecurity Risk Management Third Party Engaged [Flag]
Documents Incorporated by Reference [Text Block]
Documents Incorporated by Reference
Effective Income Tax Rate Reconciliation, Percent
Effective Income Tax Rate Reconciliation, Percent, Total
Income tax (benefit) expense, Percent
Total income tax (benefit) expense
Employee Stock Option [Member]
Income Tax Jurisdiction [Axis]
Income Tax Authority
Commitments and contingencies disclosure.
Commitments and Contingencies Disclosure [Table]
Deferred Tax Assets, Operating Loss Carryforwards, Not Subject to Expiration
NOLs carryforwards not subject to expiration
Geographical [Domain]
Geographical
Cash and Cash Equivalents, Restricted Cash and Cash Equivalents, Policy [Policy Text Block]
Cash and Cash Equivalents and Restricted Cash
Restricted Cash
Asset-Backed Securities [Member]
Asset-backed Securities [Member]
Net Income (Loss) Available to Common Stockholders, Basic [Abstract]
Numerator:
Schedule of prepaid expenses.
Schedule Of Prepaid Expenses Table [Text Block]
Schedule of Prepaid Expenses
Lessee operating lease liability tenant improvement allowance not yet received.
Lessee Operating Lease Liability Tenant Improvement Allowance Not Yet Received
Less: Tenant improvement allowance not yet received
Base rent amortized percentage
Base Rent Amortized Percentage
Base rent amortized percentage
Proceeds from issuance of common stock through registered direct offering, net of offering costs.
Proceeds From Issuance Of Common Stock Through Registered Direct Offering Net Of Offering Costs
Proceeds from issuance of common stock through registered direct offering, net of offering costs
Significant Accounting Policies [Text Block]
Summary of Significant Accounting Policies
Property, Plant and Equipment [Line Items]
Property Plant And Equipment [Line Items]
Prepaid Expense, Current [Abstract]
Liquidity and financial condition.
Liquidity And Financial Condition Policy [Text Block]
Liquidity and Financial Condition
Unusual or Infrequent Item, or Both
Unusual or Infrequent Item, or Both [Domain]
Vesting [Domain]
Vesting
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Gross
Stock options granted
Number of Outstanding Stock Options, Granted
Cybersecurity Risk Management, Strategy, and Governance [Table]
Schedule of Earnings Per Share, Basic and Diluted [Table Text Block]
Summary of Net Loss Per Share
Commission rate equal to gross proceeds.
Commission Rate Equal To Gross Proceeds1
Commission Rate Equal To Gross Proceeds1
Increase (Decrease) in Other Receivables
Other receivables
Earnings Per Share, Basic
Net loss per share - basic
Net loss per share - basic
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Number
Number of Outstanding Stock Options, Beginning Balance
Number of Outstanding Stock Options, Ending Balance
Liabilities, Current
Total current liabilities
Adjustment to Reconcile Net Income to Cash Provided by (Used in) Operating Activity [Abstract]
Adjustments to reconcile net loss to net cash used in operating activities:
Lessee, Operating Lease, Liability, to be Paid, Year Five
2030
2015 Employee Stock Purchase Plan.
Two Thousand Fifteen Employee Stock Purchase Plan [Member]
2015 Employee Stock Purchase Plan [Member]
Domestic Tax Jurisdiction [Member]
Federal [Member]
Employee Retention Credit
Employee Retention Credit Disclosure [Policy Text Block]
Employee retention credit disclosure policy text block.
Proceeds from Sale and Maturity of Debt Securities, Available-for-Sale, Total
Proceeds from Sale and Maturity of Debt Securities, Available-for-Sale
Maturities of available-for-sale investment securities
Accounting Standards Update [Axis]
Threshold qualified wages per employee per calendar quarter
Threshold Qualified Wages Per Employee Per Calendar Quarter
Threshold qualified wages per employee per calendar quarter.
Stockholders’ equity:
Equity, Attributable to Parent [Abstract]
Entity Small Business
Entity Small Business
Retained Earnings (Accumulated Deficit)
Accumulated deficit
Accumulated deficit
Retained Earnings (Accumulated Deficit), Total
Deferred Tax Assets, Tax Deferred Expense, Compensation and Benefits, Share-Based Compensation Cost
Share-based compensation expense
Accretion Expense
Debt discount accretion and non-cash interest expense
Preferred Stock [Member]
Preferred Stock
Entity Well-known Seasoned Issuer
Entity Well-known Seasoned Issuer
Deferred Tax Assets, Operating Loss Carryforwards, Subject to Expiration
NOLs carryforwards subject to expiration
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercises in Period, Intrinsic Value
Aggregate intrinsic value of stock options exercised
Legal Costs, Policy [Policy Text Block]
Patent Costs
Defined Contribution Plan [Table]
Defined Contribution Plan [Table]
Amendment Flag
Amendment Flag
Product and Service [Domain]
Product and Service
Share based compensation arrangement by share based payment award, equity instruments other than options, released in period, weighted average grant date fair value.
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Released In Period Weighted Average Grant Date Fair Value
Weighted Average Grant Date Fair Value, Released
Effective Income Tax Rate Reconciliation at Federal Statutory Income Tax Rate, Amount
U.S. federal statutory tax rate
Restricted Cash Member
Restricted Cash Member
Restricted Cash [Member]
Organization, Consolidation, Basis of Presentation, Business Description and Accounting Policies [Text Block]
Organization, Business and Basis of Presentation
Earnings Per Share, Policy [Policy Text Block]
Net Loss Per Share
Liabilities and Equity [Abstract]
Liabilities and Stockholders’ Equity
Entity Address, Postal Zip Code
Entity Address, Postal Zip Code
Net cash used in operating activities
Cash Provided by (Used in) Operating Activity, Including Discontinued Operation
Increase (Decrease) in Operating Lease Liability
Operating lease liability
Segment Reporting, CODM, Profit (Loss) Measure, How Used, Description
Common Stock [Member]
Common Stock [Member]
Cybersecurity Risk Role of Management [Text Block]
Lessee, Operating Lease, Lease Not yet Commenced, Existence of Option to Extend [true false]
Operating lease, lease not yet commenced, existence of option to extend
Defined Contribution Plan, Employer Discretionary Contribution Amount
Discretionary contribution
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Grants in Period, Weighted Average Exercise Price
Weighted Average Exercise Price, Granted
Weighted average exercise price, granted
Lessee, Operating Lease, Liability, to be Paid, Year Three
2028
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment
Less accumulated depreciation and amortization
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Total
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Beginning Balance
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Ending Balance
Non-cash expenses (depreciation and stock-based compensation)
Non-Cash Expenses Related to Research And Development Expenses
Non-cash expenses related to research and development expenses.
Debt Securities, Available-for-Sale [Line Items]
Schedule of Available-for-sale Securities [Line Items]
Accounting Standards Update 2024-03 [Member]
Entity Address, Address Line One
Entity Address, Address Line One
Change in accounting principle, accounting standards update, immaterial effect
Change in Accounting Principle, Accounting Standards Update, Immaterial Effect [true false]
Schedule of Share-Based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]
Summary of Assumptions Used to Determine Fair Value of Employee Stock Option Grants and Performance Options with Market Condition
Stock issued during period shares conversion of Preferred Stock to Common Stock.
Stock Issued During Period Shares Conversion Of Preferred Stock To Common Stock
Conversion of preferred stock to common stock, shares
Fair Value Hierarchy and NAV [Axis]
Fair Value Hierarchy and NAV
Earnings Per Share [Abstract]
Income Tax, Policy [Policy Text Block]
Income Taxes
Cybersecurity Risk Materially Affected or Reasonably Likely to Materially Affect Registrant [Flag]
Supplemental Cash Flow Information [Abstract]
Supplemental disclosure of cash flow information:
Statement of Financial Position Location, Balance [Axis]
Balance Sheet Location
Investment Type [Axis]
Investment Type
Income tax.
Income Tax [Table]
Income Tax [Table]
Operating Lease, Right-of-Use Asset
Operating lease, right-of-use assets
Finance Lease, Liability, Undiscounted Excess Amount
Less: Amount representing interest
Available-for-sale investments gross unrealized loss positions, period
Debt Securities Available For Sale Continuous Unrealized Loss Position Period
Debt securities, available-for-sale, continuous unrealized loss position period.
Income Tax Reconciliation Tax Credits Orphan Drug Credit
Income Tax Reconciliation Tax Credits Orphan Drug Credit
Orphan drug credit
Orphan drug credit
Deferred Tax Assets, Gross
Total tax assets
Cybersecurity Risk Board Committee or Subcommittee Responsible for Oversight [Text Block]
Effective Income Tax Rate Reconciliation, State and Local Jurisdiction, Contribution Greater than 50 Percent, Tax Effect [Extensible Enumeration]
Effective income tax rate reconciliation, State taxes jurisdiction, contribution greater than 50 percent, tax effect
Net Income (Loss) Attributable to Noncontrolling Interest
Net Income (Loss) Attributable to Noncontrolling Interest, Total
Net loss (gain) attributable to noncontrolling interest in Pangu BioPharma Limited
Payments to Acquire Debt Securities, Available-for-Sale
Purchases of available-for-sale investment securities
Class of Warrant or Right [Axis]
Class of Warrant or Right
Document Type
Document Type
License and Collaboration Agreements TextBlock
License and collaboration agreements
License and Collaboration Agreements
Collaborative Arrangement and Arrangement Other than Collaborative [Axis]
Collaborative Arrangement and Arrangement Other than Collaborative
Subsidiary, Ownership Percentage, Parent
Majority-owned subsidiary percentage
Stock issued during period value conversion of Preferred Stock to Common Stock.
Stock Issued During Period Value Conversion Of Preferred Stock To Common Stock
Conversion of preferred stock to common stock
Collaborative Arrangement and Arrangement Other than Collaborative [Domain]
Collaborative Arrangement and Arrangement Other than Collaborative
Entity Central Index Key
Entity Central Index Key
Debt Securities, Available-for-Sale [Table Text Block]
Schedule of Available-for-sale Investments
Proceeds from the landlord
Payments for (Proceeds from) Tenant Allowance
Investments, Debt and Equity Securities [Abstract]
Cybersecurity Risk Process for Informing Board Committee or Subcommittee Responsible for Oversight [Text Block]
Two Thousand Fourteen Stock Option Plan [Member]
Two thousand fourteen stock option plan.
2014 Plan [Member]
Remaining amount of receivable based on achievement of research milestones.
Remaining Amount Of Receivable Based On Achievement Of Research Milestones
Remaining receivable based on achievement of research milestones
Cash, Cash Equivalent, Restricted Cash, and Restricted Cash Equivalent, Period Increase (Decrease), Including Exchange Rate Effect and Discontinued Operation
Net change in cash, cash equivalents and restricted cash
Subsequent Event Type [Domain]
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount
Anti-dilutive securities not included in calculation of diluted net loss per share
Issuance of common stock from committed purchase agreement, net of offering costs in shares
Issuance Of Common Stock From Committed Purchase Agreement Net Of Offering Costs Shares
Issuance of common stock from committed purchase agreement, net of offering costs, Shares
Common Stock, Par or Stated Value Per Share
Common stock, par value
Additional allowance for tenant improvements
Additional Allowance For Tenant Improvements
Additional allowance for tenant improvements
Accounting Standards Update [Domain]
Security Deposit
Security deposit
Share-Based Payment Arrangement, Tranche One [Member]
One Year Anniversary [Member]
Operating Lease, Right-of-Use Asset, Periodic Reduction
Amortization of right-of-use assets
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Remaining Contractual Term
Weighted Average Contractual Term, Outstanding
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Volatility Rate, Maximum
Expected volatility, maximum
Debt Securities, Available-for-Sale, Amortized Cost
Gross Amortized Cost
Defined Contribution Plan Disclosure [Line Items]
Defined Contribution Plan Disclosure [Line Items]
Debt Securities, Available-for-Sale
Aggregate value of investment securities
Debt Securities, Available-for-Sale, Total
Market Value
Document Financial Statement Error Correction [Flag]
Debt Instruments [Abstract]
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercises in Period
Issuance of common stock upon exercise of stock options, Shares
Exercises
Number of Outstanding Stock Options, Exercises
Stock options exercised
Accrued Liabilities, Current
Accrued expenses
Accrued expenses
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items]
Ownership [Domain]
Ownership
Current Fiscal Year End Date
Current Fiscal Year End Date
Non-cash Research and Development Expenses
Non-cash research and development expenses.
Non-cash expenses (depreciation and stock-based compensation)
Entity Address, State or Province
Entity Address, State or Province
Jefferies LLC [Member]
Jefferies L L C [Member]
Jefferies LLC.
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Number
Number of Outstanding Restricted Stock Units, Ending Balance
Number of Outstanding Restricted Stock Units, Beginning Balance
Preferred Stock, Shares Outstanding
Preferred stock, shares outstanding
Preferred Stock, Shares Outstanding, Beginning Balance
Preferred Stock, Shares Outstanding, Ending Balance
Comprehensive Income (Loss), Net of Tax, Attributable to Parent
Comprehensive loss attributable to aTyr Pharma, Inc. common stockholders
Significant accounting policies.
Significant Accounting Policies [Table]
Significant Accounting Policies [Table]
Debt Securities, Available-for-Sale, Accumulated Gross Unrealized Gain, before Tax
Gross Unrealized Gains
Research and Development Expense, Policy [Policy Text Block]
Research and Development Costs
Common Stock, Capital Shares Reserved for Future Issuance
Common stock reserved for future issuance
Number of common stock shares reserved for issuance
Class of Warrant or Right [Domain]
Class of Warrant or Right
Geographical [Axis]
Geographical
Equity, Attributable to Noncontrolling Interest
Noncontrolling interest in Pangu BioPharma Limited
Stockholders' Equity Attributable to Noncontrolling Interest, Total
Stockholders' Equity Attributable to Noncontrolling Interest, Beginning Balance
Stockholders' Equity Attributable to Noncontrolling Interest, Ending Balance
Collaborative agreement funding received.
Collaborative Agreement Funding Received
Collaborative agreement, funding received
Other General and Administrative Expense
Other general and administrative expenses
Effective Income Tax Rate Reconciliation, State and Local Income Taxes, Amount
State and local income taxes, net of federal income tax effect
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Other, Amount
Nontaxable or nondeductible items, Other
Stock Issued During Period, Value, Stock Options Exercised
Issuance of common stock upon exercise of stock options
Schedule of Deferred Tax Assets and Liabilities [Table Text Block]
Schedule of Significant Components of Deferred Tax Assets
Other Comprehensive Income (Loss), Net of Tax [Abstract]
Other comprehensive income:
Subsequent Event [Member]
Subsequent Events [Member]
Property, Plant and Equipment [Abstract]
Deferred Tax Assets, Tax Credit Carryforwards, Research
Research and development credit carryforward
Other Assets, Noncurrent
Other assets
Debt Securities, Available-for-Sale, Current
Available-for-sale investments
Antidilutive Securities [Axis]
Antidilutive Securities
Revenue, Product and Service [Extensible Enumeration]
Share-Based Compensation Arrangement by Share-Based Payment Award, Award Vesting Rights, Percentage
Stock options vesting percentage
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period, Fair Value
Total grant date fair value of restricted stock units vested
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Abstract]
State and Local Jurisdiction [Member]
State [Member]
Share-Based Payment Arrangement, Cost by Plan [Table Text Block]
Schedule of Allocation of Stock-Based Compensation for All Stock Options and Restricted Stock Units
Available-for-Sale Securities [Member]
Available-for-sale [Member]
AOCI Attributable to Parent [Member]
Other Comprehensive Gain/(Loss) [Member]
Preferred Stock, Value, Issued
Preferred stock, $0.001 par value per share; 5,000,000 undesignated authorized shares as of December 31, 2025 and 2024, respectively; no shares issued or outstanding as of December 31, 2025 and 2024, respectively
Minimum [Member]
Minimum [Member]
Financial Instrument [Axis]
Financial Instrument
Assets, Current [Abstract]
Current assets:
Issuance Of Common Stock From Underwritten Follow On Offering Net Of Offering Costs Shares
Issuance Of Common Stock From Underwritten Follow On Offering Net Of Offering Costs Shares
Issuance of common stock from underwritten follow-on offering, net of offering costs, Shares
Class of warrant or rights warrant expiration period.
Class Of Warrant Or Rights Warrant Expiration Period
Expiration Date
Fair Value, Inputs, Level 3 [Member]
Significant Unobservable Inputs (Level 3) [Member]
License agreement abstract.
License Agreement [Abstract]
Schedule of Fair Value, Assets and Liabilities Measured on Recurring Basis [Table Text Block]
Schedule of Assets Measured at Fair Value on Recurring Basis
2015 Stock Option and Incentive Plan.
Two Thousand Fifteen Stock Option And Incentive Plan [Member]
2015 Stock Option and Incentive Plan [Member]
Liabilities, Current [Abstract]
Current liabilities:
Lease extended maturity date.
Lease Extended Maturity Date
Lease extended maturity date
2029 and thereafter
Lessee, Operating Lease, Liability Payments Due After Year Four
Lessee, operating lease, liability payments due after year four.
Shares, Outstanding
Ending balance, Shares
Beginning balance, Shares
Operating Loss Carryforwards
NOLs carryforwards
Commitments and Contingencies
Commitments and contingencies (Note 6)
Lessee, Leases [Policy Text Block]
Leases
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value
Weighted Average Grant Date Fair Value, Ending Balance
Weighted Average Grant Date Fair Value, Beginning Balance
Shareholders' Equity and Share-Based Payments [Text Block]
Stockholders' Equity
General and Administrative Expense [Member]
General and Administrative Expense [Member]
Operating Lease, Liability
Present value of lease payments
ATM offering program.
A T M Offering Program [Member]
ATM Offering Program [Member]
Auditor Firm ID
Auditor Firm ID
Description of business.
Description Of Business [Table]
Description Of Business [Table]
Net Operating Loss Carryforwards Earliest Expiration Year
Net operating loss carryforwards earliest expiration year.
NOLs carryforwards earliest expiration year
Finance Lease, Liability, Current
Current portion of financing lease liability
Less: Current portion of financing lease liability
Finance Lease, Weighted Average Discount Rate, Percent
Financing lease, weighted-average discount rate
Effective Income Tax Rate Reconciliation, Change in Deferred Tax Assets Valuation Allowance, Percent
Changes in valuation allowances
Net Income (Loss), Including Portion Attributable to Noncontrolling Interest
Consolidated net loss
Consolidated net loss
Net loss
Consolidated net loss
Income Tax Reconciliation Nondeductible Expense Imputed Interest
Income Tax Reconciliation Nondeductible Expense Imputed Interest
Nontaxable or nondeductible items, Imputed interest
Segment Reporting, Measurement Disclosures [Abstract]
Cybersecurity Risk Management Positions or Committees Responsible [Text Block]
Weighted Average Number of Shares Outstanding, Basic, Total
Weighted Average Number of Shares Outstanding, Basic
Shares used in computing net loss per share, basic
Scenario [Axis]
Scenario
Leases, Operating [Abstract]
Effective Income Tax Rate Reconciliation, Other Reconciling Items, Amount
Effective Income Tax Rate Reconciliation, Other Reconciling Items, Amount, Total
Other reconciling items
Loss Contingency, Name of Defendant
Schedule of Effective Income Tax Rate Reconciliation [Table Text Block]
Schedule of Effective Income Tax Rate Reconciliation
Schedule of Reconciliation of U.S. Federal Statutory Rate to Effective Rate
Deferred Tax Liabilities, Leasing Arrangements
Right of use lease assets
Schedule of Share-Based Compensation Arrangements by Share-Based Payment Award [Table]
Schedule Of Share Based Compensation Arrangements By Share Based Payment Award [Table]
Long-Lived Tangible Asset [Domain]
Long-Lived Tangible Asset
Cybersecurity Risk Process for Informing Management or Committees Responsible [Text Block]
Milestone payment received.
Milestone Payment Received
Milestone payments received
Deferred Tax Assets, Net [Abstract]
Deferred tax assets:
Employee retention credit benefits refund received
Employee Retention Credit Benefits Refund Received
Employee retention credit benefits refund received.
APIC, Share-Based Payment Arrangement, Increase for Cost Recognition
Stock-based compensation
APIC, Share-Based Payment Arrangement, Increase for Cost Recognition, Total
Deferred Tax Asset, In-Process Research and Development
Capitalized research and development expenses
Effective Income Tax Rate Reconciliation, Change in Deferred Tax Assets Valuation Allowance, Amount
Change in valuation allowances
Equity, Attributable to Parent
Total aTyr Pharma stockholders’ equity
Stockholders' Equity Attributable to Parent, Beginning Balance
Stockholders' Equity Attributable to Parent, Ending Balance
Preferred Stock, Par or Stated Value Per Share
Preferred stock, par value
Collaboration revenue.
Collaboration Revenue [Member]
Collaboration Revenue [Member]
Basis of Accounting, Policy [Policy Text Block]
Organization and Business
Lessee, Operating Lease, Existence of Option to Extend [true false]
Lease, option to extend
Statement of Stockholders' Equity [Abstract]
Lessee Operating Lease Liability Undiscounted Excess Interest Amount
Lessee Operating Lease Liability Undiscounted Excess Interest Amount
Less: Amount representing interest
Deferred tax assets, tax credit carryforwards, research and other state.
Deferred Tax Assets Tax Credit Carryforwards Research And Other State
Research credits and other state credits
Share-Based Payment Arrangement, Tranche Two [Member]
Share-based Payment Arrangement, Tranche Two
Prepaid manufacturing expenses.
Prepaid Manufacturing Expenses [Member]
Prepaid Manufacturing Expenses [Member]
Use of Estimates, Policy [Policy Text Block]
Use of Estimates
Allowance of Credit Losses
Credit Loss, Financial Instrument [Policy Text Block]
Entity Address, Address Line Two
Entity Address, Address Line Two
Fair Value Disclosures [Text Block]
Fair Value Measurements
Finance Lease, Liability, to be Paid, Maturity [Table Text Block]
Schedule of Future Minimum Payments under Non-cancelable Financing Lease and Reconciliation to Financing Lease Liability
Warrants and Rights Note Disclosure [Abstract]
Noncontrolling Interest [Member]
Noncontrolling Interest [Member]
Annual upward adjustments on base rate percentage.
Annual Upward Adjustments on Base Rate Percentage
Annual upward adjustments on base rate, percentage
Schedule of Accrued Liabilities [Table Text Block]
Summary of Accrued Expenses
Schedule of Unrecognized Tax Benefits Roll Forward [Table Text Block]
Schedule of Activity Related to Unrecognized Tax Benefits
Segment Reporting, CODM, Individual Title and Position or Group Name [Extensible Enumeration]
Other segment items
Segment Reporting, Other Segment Item, Amount
Other segment items
Plan Name [Domain]
Plan Name
Schedule of Share-Based Payment Award, Employee Stock Purchase Plan, Valuation Assumptions [Table Text Block]
Summary of Assumptions Used to Determine Fair Value of Employee Stock Purchase Plan
Aspire capital member
Aspire Capital [Member]
Aspire Capital [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Cybersecurity Risk Materially Affected or Reasonably Likely to Materially Affect Registrant [Text Block]
Impairment, Long-Lived Asset, Held-for-Use
Impairment of long lived assets
Impairment, Long-Lived Asset, Held-for-Use, Total
Cybersecurity Risk Management Expertise of Management Responsible [Text Block]
Finance Lease, Liability, to be Paid, Year One
2026
Share-Based Compensation Arrangement by Share-Based Payment Award, Award Vesting Rights
Stock options vesting period, description
Class of Warrant or Right, Outstanding
Number Outstanding
Employee retention credit receivable - research and development expenses
Employee Retention Credit Receivable Research And Development Expenses
Employee retention credit receivable research and development expenses.
Class of Warrant or Right [Table]
Class Of Warrant Or Right [Table]
Foreign Tax Jurisdiction [Member]
Foreign [Member]
Non-Cash Expenses Related to General And Administrative Expenses
Non-cash expenses related to general and administrative expenses.
Non-cash expenses (depreciation and stock-based compensation)
Property and Equipment
Property, Plant and Equipment, Policy [Policy Text Block]
Weighted Average Number of Shares, Common Stock Subject to Repurchase or Cancellation
Weighted average common shares subject to repurchase
Area of Real Estate Property
Area of office and laboratory space
Entity Address, City or Town
Entity Address, City or Town
Deferred Tax Assets Lease Liability
Lease liability
Deferred tax assets lease liability.
Change in unrecognized tax benefits
Increase in Unrecognized Tax Benefits is Reasonably Possible
Proceeds from issuance of common stock under employee stock purchase plan
Proceeds From Issuance Of Common Stock Under Employee Stock Purchase Plan
Proceeds from issuance of common stock through employee stock purchase plan
Long-term purchase commitment, period
Long-Term Purchase Commitment, Period
Security Exchange Name
Security Exchange Name
At The Market Offering Program.
At Market Offering Program [Member]
ATM Offering Program [Member]
Property, Plant and Equipment, Gross
Property and equipment, Gross
Property, Plant and Equipment, Gross, Total
Property, Plant and Equipment, Gross, Beginning Balance
Property, Plant and Equipment, Gross, Ending Balance
Kyorin pharmaceutical co ltd .
Kyorin Pharmaceutical Co Ltd [Member]
Kyorin Pharmaceutical Co Ltd [Member]
Stock option maximum term.
Stock Option Maximum Term
Maximum term for stock option plan grant
Counterparty Name [Axis]
Counterparty Name
Income (Loss) from Continuing Operations before Income Taxes, Noncontrolling Interest
Worldwide pre-tax loss
Finance Lease, Liability, to be Paid, Year Five
2027
Scientific and laboratory equipment.
Scientific And Laboratory Equipment [Member]
Scientific and Laboratory Equipment [Member]
Antidilutive Securities, Name [Domain]
Antidilutive Securities, Name
Effective Income Tax Rate Reconciliation, Foreign Income Tax Rate Differential, Percent
Foreign tax rate effects/differential
Deferred Tax Assets, Goodwill and Intangible Assets
Intangible assets
Jones Trading Institutional Services LLC [Member]
Jones Trading Institutional Services L L C [Member]
Jones trading institutional services LLC
Interest Paid, Excluding Capitalized Interest, Operating Activity
Interest paid
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table]
Schedule Of Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Table]
Statistical Measurement [Domain]
Statistical Measurement
Class of Warrant or Right, Exercise Price of Warrants or Rights
Exercise Price Per Share
Assets, Current
Total current assets
Share-Based Payment Arrangement, Expense
Stock-based compensation
Total stock-based compensation expense
Document Period End Date
Document Period End Date
Purchases of property and equipment in accounts payable.
Purchases of Property and Equipment in Accounts Payable
Purchases of property and equipment in accounts payable
Title and Position [Axis]
Fair Value Hierarchy and NAV [Domain]
Fair Value Hierarchy and NAV
ICFR Auditor Attestation Flag
ICFR Auditor Attestation Flag
Gain (Loss) on Disposition of Property Plant Equipment
Gain (Loss) on Disposition of Property Plant Equipment, Total
Gain on disposal of property and equipment
Development regulatory and sales milestone member.
Development Regulatory And Sales Milestone [Member]
Development Regulatory And Sales Milestones [Member]
Statement of Financial Position [Abstract]
Restricted Stock Units (RSUs) [Member]
Restricted Stock Unit [Member]
Revenue [Policy Text Block]
Revenue Recognition
Antidilutive Security, Excluded EPS Calculation [Table]
Schedule Of Antidilutive Securities Excluded From Computation Of Earnings Per Share [Table]
Vesting [Axis]
Vesting
Warrant four.
Warrant Four [Member]
Warrant Four [Member]
Defined contribution plan date of plan beginning.
Defined Contribution Plan Date Of Plan Beginning
Date of Policy beginning
Class of Stock [Axis]
Class of Stock
Debt Securities, Available-for-Sale, Unrealized Loss Position, Number of Positions
Available-for-sale, investments in unrealized loss positions, number of positions
Deferred Tax Liabilities, Net
Total deferred tax liabilities
Deferred Tax Liabilities, Net, Total
Compensation and Employee Benefit Plans [Text Block]
Employee Benefits
Warrant three.
Warrant Three [Member]
Warrant Three [Member]
Issuance of common stock from committed purchase agreement, net of offering costs
Issuance Of Common Stock From Committed Purchase Agreement Net Of Offering Costs
Issuance of common stock from committed purchase agreement, net of offering costs
Cybersecurity Risk Management, Strategy, and Governance [Line Items]
Effective Income Tax Rate Reconciliation, Change in Enacted Tax Rate, Percent
Change in tax rate
Effective Income Tax Rate Reconciliation, Tax Settlement, Percent
Percentage of tax benefit to be realized upon settlement
Effective Income Tax Rate Reconciliation, Tax Settlement, Percent, Total
Tenant Improvements
Allowance for tenant improvements
Finance Lease Liability Undiscounted Excess Interest Amount
Finance lease liability undiscounted excess interest amount.
Less: Amount representing interest
Financial Instruments [Domain]
Financial Instruments
Commitments and contingencies disclosure.
Commitments and Contingencies Disclosure [Line Items]
Commitments and Contingencies [Line Items]
Effective Income Tax Rate Reconciliation, Foreign Income Tax Rate Differential, Amount
Foreign tax rate effects/differential
Deferred Tax Assets, Tax Deferred Expense, Reserves and Accruals
Reserve and accruals
Deferred Tax Assets, Tax Deferred Expense, Reserves and Accruals, Total
Lessee, Operating Lease, Liability, to be Paid, Year Two
2027
Debt Securities, Available-for-Sale, Continuous Unrealized Loss Position, 12 Months or Longer, Number of Positions
Available-for-sale, investments in unrealized loss positions, greater than 12 months
Weighted Average Number of Shares Outstanding, Diluted, Total
Weighted Average Number of Shares Outstanding, Diluted
Shares used in computing net loss per share, diluted
Entity File Number
Entity File Number
Net unrealized gain (loss) on investments, net of tax
OCI, Debt Securities, Available-for-Sale, Unrealized Holding Gain (Loss), before Adjustment, after Tax
Change in unrealized gain on available-for-sale investments, net of tax
Effective Income Tax Rate Reconciliation, Other Reconciling Items, Percent
Other reconciling items
Accounting Standards Update 2023-07 [Member]
Cover
Cover [Abstract]
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Volatility Rate, Minimum
Expected volatility, minimum
General Business Tax Credit Carryforward [Member]
Orphan Drug Credits [Member]
Increase (Decrease) in Accounts Payable and Accrued Liabilities
Accounts payable and accrued expenses
Increase (Decrease) in Accounts Payable and Accrued Liabilities, Total
Tenant improvements.
Tenant Improvements [Member]
Tenant Improvements [Member]
Investments [Domain]
Investments
Supplemental Balance Sheet Disclosures [Text Block]
Balance Sheet Details
Scenario [Domain]
Scenario
Number of Operating Segments
Number of operating segment
Sale of Stock [Domain]
Sale of Stock
General and Administrative Expense
General and administrative
Total general and administrative expenses
Total general and administrative expenses
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Research And Development Arrangement Contract To Perform For Others [Line Items]
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Forfeitures and Expirations in Period
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Forfeitures and Expirations in Period, Total
Number of Outstanding Stock Options, Canceled/forfeited/expired
Effective Income Tax Rate Reconciliation, Change in Enacted Tax Rate, Amount
Change in tax rate
Operating Lease, Expense
Operating lease expense
Period of change in ownership.
Period Of Change In Ownership
Period of change in ownership
Property, Plant and Equipment, Useful Life
Estimated useful life of property and equipment
New Accounting Pronouncements, Policy [Policy Text Block]
Recent Accounting Pronouncements
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Inducement pool non-qualified option.
Inducement Pool Non Qualified Option [Member]
Inducement Pool Non Qualified Option
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Other, Percent
Nontaxable or nondeductible items, Other
Ownership [Axis]
Ownership
Share-Based Compensation Arrangement by Share-Based Payment Award, Award Vesting Period
Stock options vesting period
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Risk Free Interest Rate, Minimum
Risk-free interest rate, minimum
Income (Loss) from Continuing Operations before Income Taxes, Domestic
United States
Income Tax Expense (Benefit), Effective Income Tax Rate Reconciliation, Amount [Abstract]
Investment, Type [Extensible Enumeration]
Share-Based Payment Arrangement, Nonvested Award, Excluding Option, Cost Not yet Recognized, Amount
Unrecognized share based compensation expense related to restricted stock units
Other Receivables, Net, Current
Other receivables
Other Receivables, Net, Current, Total
Operating lease, term of lease
Lessee, Operating Lease, Term of Contract
Common Stock, Shares, Outstanding
Common stock, shares outstanding
Common Stock, Shares, Outstanding, Beginning Balance
Common Stock, Shares, Outstanding, Ending Balance
Operating Lease, Liability, Current
Current portion of operating lease liability
Less: Current portion of operating lease liability
Depreciation, Depletion and Amortization
Depreciation and amortization
Depreciation expense
Depreciation, Depletion and Amortization, Total
Cybersecurity Risk Management Processes Integrated [Flag]
Document Transition Report
Document Transition Report
Deferred Tax Assets, Net
Net deferred tax assets
Short-term investments
Short-Term Investments
Short-Term Investments, Total
Operating Expenses
Total operating expenses
Accrued Liabilities, Current [Abstract]
Research and development
Capitalization of R&D costs
Total research and development expense
Total research and development expenses
Cost of Revenue
Stand-alone selling price of license
Cost of Revenue, Total
Convertible Preferred Stock [Member]
Convertible Preferred Stock
Convertible Preferred Stock [Member]
Proceeds from issuance of common stock through committed purchase agreement net of offering costs.
Proceeds From Issuance Of Common Stock Through Committed Purchase Agreement Net Of Offering Costs
Proceeds from issuance of common stock from committed purchase agreement, net of offering costs
Litigation Status [Axis]
Comprehensive Income (Loss), Net of Tax, Including Portion Attributable to Noncontrolling Interest
Comprehensive loss
Statement of Cash Flows [Abstract]
Effective Income Tax Rate Reconciliation Nondeductible Expense Imputed Interest
Effective Income Tax Rate Reconciliation Nondeductible Expense Imputed Interest
Nontaxable or nondeductible items, Imputed interest
HONG KONG
Hong Kong [Member]
Share-Based Payment Arrangement, Option, Activity [Table Text Block]
Summary of Stock Option Activity
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Share-Based Payment Arrangement, Percent
Nontaxable or nondeductible items, Stock compensation
Base rent per square foot
Base Rent Per Square Foot
Base rent per square foot
Share-Based Payment Arrangement, Restricted Stock Unit, Activity [Table Text Block]
Schedule of Restricted Stock Units Activity
Cybersecurity Risk Management Processes Integrated [Text Block]
Net loss attributable to aTyr Pharma, Inc.
Net loss attributable to aTyr Pharma, Inc.
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Intrinsic Value
Aggregate Intrinsic Value, Outstanding
Commitment to purchase shares
Long-Term Purchase Commitment, Amount
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Dividend Rate
Expected dividend yield
Assets [Abstract]
Assets
Description of business.
Description Of Business [Line Items]
Description Of Business [Line Items]
Entire disclosure of license, collaboration and other agreements.
License Collaboration And Other Agreements [Text Block]
License, Collaboration and Other Agreements
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Risk Free Interest Rate
Risk-free interest rate
Increase (Decrease) in Prepaid Expense and Other Assets
Prepaid expenses and other assets
Repayments of Debt
Repayments on borrowings
Document Fiscal Year Focus
Document Fiscal Year Focus
Two thousand fifteen stock plan.
Two Thousand Fifteen Stock Plan [Member]
Shares Available Under the 2015 Plan [Member]
Cash Provided by (Used in) Investing Activity, Including Discontinued Operation [Abstract]
Cash flows from investing activities:
Retirement Benefits [Abstract]
Accounts Payable, Current
Accounts payable
Accounts Payable, Current, Total
Schedule of Income before Income Tax, Domestic and Foreign [Table Text Block]
Schedule of Pretax Losses for Domestic and Foreign Operations
Research and Development Expense [Member]
Research and Development Expense [Member]
Four hundred one plan.
Four Hundred One Plan [Member]
401 (k) Plan [Member]
Defined Contribution Plan, Employer Matching Contribution, Percent of Match
Percentage of match employee contribution
Transaction Type [Axis]
Transaction Type
Pending Litigation [Member]
Capitalized research and development costs amortization period.
Capitalized Research And Development Costs Amortization Period
Amortization period of capitalized R&D costs
Lessee, Operating Lease, Lease Not yet Commenced, Term of Contract
Operating lease, lease not yet commenced, term of contract
Stock issued during period shares at registered direct offering net of offering costs.
Stock Issued During Period Shares At Registered Direct Offering Net Of Offering Costs
Issuance of common stock from registered direct offering, net of offering costs, Shares
Fair Value Disclosures [Abstract]
Commitments and Contingencies Disclosure [Abstract]
Lessee, Operating Lease, Liability, to be Paid, Year One
2026
Issuance Of Common Stock From Underwritten Follow On Offering Net Of Offering Costs
Issuance of common stock from underwritten follow-on offering, net of offering costs
Issuance Of Common Stock From Underwritten Follow On Offering Net Of Offering Costs
Warrant five.
Warrant Five [Member]
Warrant Five [Member]
Lessee, Operating Lease, Liability, to be Paid, after Year Five
2030 and thereafter
Share-Based Payment Arrangement [Abstract]
Assets, Fair Value Disclosure
Total assets measured at fair value
Sale of Stock [Axis]
Sale of Stock
Cash Provided by (Used in) Investing Activity, Including Discontinued Operation
Net cash (used in) provided by investing activities
Jones trading.
Jones Trading [Member]
Cowen Company, LLC (Cowen) [Member]
Finance Lease, Weighted Average Remaining Lease Term
Financing lease, weighted-average remaining lease term
Title of 12(b) Security
Title of 12(b) Security
Schedule of Segment Reporting Information, by Segment [Table]
Deferred Tax Liabilities, Net [Abstract]
Deferred tax liabilities:
Cares Act [Member]
Cares Act [Member]
Cares act.
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Share-Based Payment Arrangement, Amount
Nontaxable or nondeductible items, Stock compensation
Lessee, Operating Lease, Lease Not yet Commenced, Option to Extend
Operating lease, lease not yet commenced, option to extend
Income Tax Disclosure [Text Block]
Income Tax
Proceeds from issuance of common stock through at market offering net of offering costs.
Proceeds From Issuance Of Common Stock Through At Market Offering Net Of Offering Costs
Proceeds from issuance of common stock from at-the-market offerings, net of offering costs
Stock issued during period value at registered direct offering net of offering costs.
Stock Issued During Period Value At Registered Direct Offering Net Of Offering Costs
Issuance of common stock from registered direct offering, net of offering costs
Class of Warrant or Right [Line Items]
Class Of Warrant Or Right [Line Items]
Weighted Average Number of Shares Issued, Basic
Weighted average common shares outstanding
Financing lease, right-of-use assets
Finance Lease, Right-of-Use Asset, after Accumulated Amortization, Total
Finance Lease, Right-of-Use Asset, after Accumulated Amortization
Adjustment to Reconcile Net Income to Cash Provided by (Used in) Operating Activity, Increase (Decrease) in Operating Capital [Abstract]
Changes in operating assets and liabilities:
Operating loss carryforwards expiration year.
Operating Loss Carryforwards Expiration Year
NOLs carryforwards expiration year
Property, Plant and Equipment [Table Text Block]
Summary of Property and Equipment
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Exercise Price
Weighted Average Exercise Price, Ending Balance
Weighted Average Exercise Price, Beginning Balance
Proceeds, Issuance of Shares, Share-Based Payment Arrangement, Including Option Exercised
Proceeds from issuance of common stock through option exercises
Proceeds, Issuance of Shares, Share-Based Payment Arrangement, Including Option Exercised, Total
Purchases of fixed assets included in accounts payable.
Purchases Of Fixed Assets Included In Accounts Payable
Purchase of fixed assets included in accounts payable
Class X convertible preferred stock (if-converted).
Class X Convertible Preferred Stock If Converted [Member]
Class X Preferred Stock (if-converted to common stock) [Member]
Income Tax Disclosure [Abstract]
Fair Value, Recurring and Nonrecurring [Table]
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Table]
Unrecognized Tax Benefits
Balance as of end of year
Balance as of beginning of year
Additional Paid-in Capital [Member]
Additional Paid-In Capital [Member]
Measurement Frequency [Domain]
Measurement Frequency
Purchase Agreement Member.
Purchase Agreement [Member]
Purchase Agreement [Member]
Income Statement Location
Statement of Income Location, Balance [Axis]
Change in accounting principle, accounting standards update, adoption date
Change in Accounting Principle, Accounting Standards Update, Adoption Date
Trading Symbol
Trading Symbol
Tabular disclosure of future minimum payments required in the aggregate and for each of the five succeeding fiscal years for operating lease.
Schedule Of Future Minimum Rental Payments For Operating Lease Table [Text Block]
Schedule of Future Minimum Payments under Non-cancelable Operating Lease and Reconciliation to Operating Lease Liability
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Risk Free Interest Rate, Maximum
Risk-free interest rate, maximum
Subsequent Event Type [Axis]
Deferred tax assets, tax credit carryforwards, research expiration year.
Deferred Tax Assets Tax Credit Carryforwards Research Expiration Year
Research and development credit carryforward expiration year
Employee-related Liabilities, Current
Accrued salaries, wages and benefits
Employee-related Liabilities, Current, Total
Cash Provided by (Used in) Financing Activity, Including Discontinued Operation [Abstract]
Cash flows from financing activities:
Lessee, Finance Lease, Term of Contract
Financing lease, term of contract
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Term
Expected term (in years)
Fair Value, Recurring [Member]
Fair Value, Measurements, Recurring [Member]
Accounting Standards Update 2016-13 [Member]
Lessee, Operating Lease, Liability, Undiscounted Excess Amount
Less: Amount representing interest
Lessee operating lease, lease commencement date
Lessee Operating Lease, Lease Commencement Date
Lessee Operating Lease, Lease Commencement Date
Effective Income Tax Rate Reconciliation, Tax Credit, Research, Percent
Research credits, Percent
Research and development credits
Research and development credits
Other than Temporary Impairment, Credit Losses Recognized in Earnings, Categories of Investments [Domain]
Other than Temporary Impairment, Credit Losses Recognized in Earnings, Categories of Investments
Equity Components [Axis]
Other Comprehensive Gain/(Loss) [Member]
Stock issued during period shares at the market offerings net of offering costs.
Stock Issued During Period Shares At The Market Offerings Net Of Offering Costs
Issuance of common stock from at the market offerings, net of offering costs, Shares
Nonoperating Income (Expense)
Total other income (expense), net
Nonoperating Income (Expense), Total
Equity Component [Domain]
Equity Component
Asset Class [Axis]
Asset Class
Stock issued during period value at the market offerings net of offering costs.
Stock Issued During Period Value At The Market Offerings Net Of Offering Costs
Issuance of common stock from at-the-market offerings, net of offering costs
Document Annual Report
Document Annual Report
IPO [Member]
IPO [Member]
Stock Issued During Period, Shares, Employee Stock Purchase Plans
Issuance of common stock pursuant to employee stock purchase plan, Shares
Warrant one.
Warrant One [Member]
Warrant One [Member]
Effective Income Tax Rate Reconciliation, Tax Contingency, Amount
Effective Income Tax Rate Reconciliation, Tax Contingency, Amount, Total
Changes in unrecognized tax benefits
Statement of Comprehensive Income [Abstract]
Accrued clinical studies costs.
Accrued Clinical Studies Costs
Accrued clinical and manufacturing
Maximum [Member]
Maximum [Member]
Maximum [Member]
Statistical Measurement [Axis]
Statistical Measurement
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Exercises in Period, Weighted Average Exercise Price
Weighted Average Exercise Price, Exercised
Prepaid Expense, Current, Total
Prepaid Expense, Current
Prepaid expenses
Common Stock, Value, Issued
Common stock, $0.001 par value per share; 170,000,000 authorized shares as of December 31, 2025 and 2024, respectively; issued and outstanding shares - 98,031,104 as of December 31, 2025 and 84,038,922 as of December 31, 2024, respectively
Finance Lease, Principal Payments
Principal paid on finance lease liabilities
Litigation Status [Domain]
Defined contribution plan approved month and year.
Defined Contribution Plan Approved Month And Year
Policy approved month and year
Consolidation, Policy [Policy Text Block]
Principles of Consolidation
Equity, Including Portion Attributable to Noncontrolling Interest
Ending balance
Beginning balance
Total stockholders' equity
Equipment [Member]
Leased Equipment [Member]
Efzofitimod Expenses
Efzofitimod Expenses.
Efzofitimod expenses
Deferred Tax Assets, Operating Loss Carryforwards
Net operating loss carryforwards
Deferred Tax Assets, Operating Loss Carryforwards, Total
Cybersecurity Risk Management Processes for Assessing, Identifying, and Managing Threats [Text Block]
Tax Credit Carryforward [Axis]
Tax Credit Carryforward
Impairment or Disposal of Long-Lived Assets, Policy [Policy Text Block]
Impairment of Long-Lived Assets
Effective Income Tax Rate Reconciliation, State and Local Income Taxes, Percent
State income taxes, net of federal benefit, Percent
State and local income taxes, net of federal income tax effect
Entity Public Float
Entity Public Float
Significant account policies line items.
Significant Accounting Policies [Line Items]
Significant Accounting Policies [Line Items]
Pangu BioPharma Limited.
Pangu Bio Pharma Limited [Member]
Pangu BioPharma [Member]
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Volatility Rate
Expected volatility
Preferred Stock, Shares Authorized
Preferred stock, shares authorized
Comprehensive Income (Loss), Net of Tax, Attributable to Noncontrolling Interest
Comprehensive Income (Loss), Net of Tax, Attributable to Noncontrolling Interest, Total
Comprehensive loss (gain) attributable to noncontrolling interest in Pangu BioPharma Limited
Debt Security Category [Axis]
Debt Security Category
Employee stock purchase plan.
Employee Stock Purchase Plan [Member]
Employee Stock Purchase Plan [Member]
Shares Available Under the Employee Stock Purchase Plan [Member]
Employee Stock [Member]
ESPP [Member]
Entity Registrant Name
Entity Registrant Name
Unrecognized Tax Benefits, Income Tax Penalties and Interest Accrued
Unrecognized tax benefits, income tax penalties and interest accrued
Unrecognized Tax Benefits, Income Tax Penalties and Interest Accrued, Total
Debt Securities, Available-for-Sale, Accumulated Gross Unrealized Loss, before Tax
Gross Unrealized Losses
Entity Voluntary Filers
Entity Voluntary Filers
Share based compensation arrangement by share based payment award, equity instruments other than options, released in period.
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Released In Period
Number of Outstanding Restricted Stock Units, Released
Additional Paid in Capital
Additional paid-in capital
Additional Paid in Capital, Total
Accrued interest receivable on available-for-sale
Debt Securities Available For Sale Accrued Interest
Debt Securities Available For Sale Accrued Interest
Cybersecurity Risk Management Positions or Committees Responsible [Flag]
Income Tax Expense (Benefit)
Income tax (benefit) provision
Total income tax (benefit) expense
Measurement Frequency [Axis]
Measurement Frequency
Shares Available Under the 2022 Inducement Plan [Member]
Two Thousand Twenty Two Inducement Plan [Member]
Two thousand twenty two inducement plan.
2022 Inducement Plan
Proceeds from Issuance of Common Stock
Proceeds from Issuance of Common Stock
Net proceeds from issuance of common stock
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Entity Common Stock, Shares Outstanding
Entity Common Stock, Shares Outstanding
Concentration Risk, Credit Risk, Policy [Policy Text Block]
Concentration of Credit Risk
Compensation Related Costs, Policy [Policy Text Block]
Stock-Based Compensation
Accumulated Other Comprehensive Income (Loss), Net of Tax
Accumulated other comprehensive loss
Accumulated Other Comprehensive Income (Loss), Net of Tax, Total
Payments to Acquire Property, Plant, and Equipment
Purchases of property and equipment
Payments to Acquire Property, Plant, and Equipment, Total
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period
Restricted stock units granted
Assets
Total assets
Employee retention of payroll expenses
Employee Retention Of Payroll Expenses
Employee retention of payroll expenses.
Property, Plant and Equipment [Table]
Schedule Of Property Plant And Equipment [Table]
Balance sheet details.
Balance Sheet Details [Abstract]
Income Statement [Abstract]
Retirement Plan Name [Domain]
Retirement Plan Name
Unrecognized Tax Benefits, Decrease Resulting from Prior Period Tax Positions
Decrease related to prior year tax positions
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Aggregate Intrinsic Value, Outstanding
Aggregate intrinsic value of restricted stock units
Cash and cash equivalents restricted cash and available for sale investments.
Cash And Cash Equivalents Restricted Cash And Available For Sale Investments
Cash, cash equivalents, available-for-sale investments and restricted cash
Upfront and milestone payments received
Upfront and Milestone Payment Received
Upfront and milestone payment received.
Stock Issued During Period, Shares, New Issues
Number of shares issued and sold
Sales agreement.
Sales Agreement [Member]
Sale Agreement [Member]
NOLs carryforwards latest expiration year
Net Operating Loss Carryforwards Latest Expiration Year
Net operating loss carryforwards latest expiration year.
Net loss per share - diluted
Net loss Per Share, Diluted
Net loss per share - diluted
Percentage of employee retention credit benefit can be claimed on qualified wages
Percentage Of Employee Retention Credit Benefit Can Be Claimed On Qualified Wages
Percentage of employee retention credit benefit can be claimed on qualified wages.
Prepaid Expenses [Line Items]
Prepaid Expenses [Line Items]
Prepaid Expenses [Line Items]
Schedule of Segment Reporting Information, by Segment [Table Text Block]
Summary of Significant Expense Categories Reviewed by CODM
Effective Income Tax Rate Reconciliation, Percent [Abstract]
Title and Position [Domain]
City Area Code
City Area Code
Auditor Name
Auditor Name
Finance Lease, Liability, Noncurrent
Long-term financing lease liability, net of current portion
Class X convertible preferred stock.
Class X Convertible Preferred Stock [Member]
Class X Convertible Preferred Stock [Member]
Unusual or Infrequent Item, or Both
Unusual or Infrequent Item, or Both [Axis]
Percentage of change in ownership.
Percentage Of Change In Ownership
Percentage of change in ownership
Change in accounting principle, accounting standards update, early adoption
Change in Accounting Principle, Accounting Standards Update, Early Adoption [true false]
Preclinical Development And Other Shared Research And Development Expense
Preclinical Development And Other Shared Research And Development Expense
Preclinical development and other shared research and development expenses
Counterparty Name [Domain]
Counterparty Name
Effective Income Tax Rate Reconciliation, Tax Credit, Research, Amount
Research and development credits
Stock Issued During Period, Value, Employee Stock Purchase Plan
Issuance of common stock pursuant to employee stock purchase plan
Operating Lease, Weighted Average Remaining Lease Term
Operating lease, weighted average remaining lease term
Segment Reporting Information [Line Items]
Retirement Plan Name [Axis]
Retirement Plan Name
Debt commitments and contingencies.
Debt Commitments And Contingencies [Text Block]
Commitments and Contingencies
Effective Income Tax Rate Reconciliation Tax Credits Orphan Drug Credit
Effective Income Tax Rate Reconciliation Tax Credits Orphan Drug Credit
Orphan drug credit
Orphan drug credit
Property, Plant and Equipment, Net
Property and equipment, net
Property and equipment, Net
Cash, Cash Equivalent, Restricted Cash, and Restricted Cash Equivalent, Including Discontinued Operation
Cash, cash equivalents and restricted cash at beginning of period
Cash, cash equivalents and restricted cash at end of period
Cash, cash equivalents and restricted cash at the end of period
Operating Income (Loss)
Loss from operations
Retained Earnings [Member]
Accumulated Deficit [Member]
Transaction [Domain]
Transaction
H.C. Wainwright & Co., LLC Member.
H C Wainwright Co L L C [Member]
H.C. Wainwright & Co., LLC [Member]
Lease extended maturity term.
Lease extended maturity Term
Debt Securities, Available-for-Sale, Continuous Unrealized Loss Position, Less than 12 Months
Available-for-sale, investments in unrealized loss positions, less than twelve months, market value
Income tax.
Income Tax [Line Items]
Income Tax [Line Items]
Operating Lease, Weighted Average Discount Rate, Percent
Operating lease, weighted average discount rate
Operating Lease, Liability, Noncurrent
Long-term operating lease liability, net of current portion
Fair Value, Inputs, Level 1 [Member]
Quoted Prices in Active Markets for Identical Assets (Level 1) [Member]
Cash Provided by (Used in) Financing Activity, Including Discontinued Operation
Net cash provided by financing activities
Change in accounting principle, accounting standards update, adopted
Change in Accounting Principle, Accounting Standards Update, Adopted [true false]
Auditor Location
Auditor Location
Available for sale securities effective maturity period.
Available For Sale Securities Effective Maturity Period
Available-for-sale investments effective maturity period
Investments, Fair Value Disclosure, Total
Investments, Fair Value Disclosure
Investments, fair value
Schedule of Stockholders' Equity Note, Warrants or Rights [Table Text Block]
Summary of Warrants Outstanding
Loss Contingency, Name of Plaintiff
Loss contingency, name of plaintiff
Schedule of Potentially Dilutive Securities Not Included in Calculation of Diluted Net Loss Per Share
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block]
Estimated Litigation Liability
Estimated litigation liabillity
Corporate Debt Securities [Member]
Corporate Debt Securities [Member]
Income Tax Jurisdiction [Domain]
Income Tax Authority
Debt Securities, Available-for-Sale [Table]
Entity Interactive Data Current
Entity Interactive Data Current
Research and Development, Contract to Perform for Others [Table]
Schedule Of Research And Development Arrangement Contract To Perform For Others [Table]
Increase (Decrease) in Contract with Customer, Liability
Contract liability
Statement of Income Location, Balance [Domain]
Income Statement Location
Costs and Expenses, Related Party
Expenses
accrued expenses.
Accrued Expenses Policy [Text Block]
Accrued Expenses
Lessee, Operating Lease, Lease Not yet Commenced, Renewal Term
Operating lease, lease not yet commenced, extension term
Cash Provided by (Used in) Operating Activity, Including Discontinued Operation [Abstract]
Cash flows from operating activities:
Accretion (Amortization) of Discounts and Premiums, Investments
Accretion of discount of available-for-sale investment securities
Upfront payment received.
Upfront Payment Received
Upfront payment received
Funding Of Project Cost Description
Funding of project cost, description
Funding of project cost, description.
Entity Tax Identification Number
Entity Tax Identification Number
Public offerings member.
Public Offerings [Member]
Public Offerings [Member]
Prepaid Expenses [Table]
Prepaid Expenses [Table]
Prepaid Expenses [Table]
Local Phone Number
Local Phone Number
Share-Based Payment Arrangement, Nonvested Award, Option, Cost Not yet Recognized, Amount
Unrecognized share based compensation expense related to unvested stock options
Weighted Average Number of Shares Outstanding, Diluted [Abstract]
Denominator:
Auditor Opinion [Text Block]
Finance Lease, Liability, to be Paid, Year Two
2027
Accounting Policies [Abstract]
Research and development costs capitalized.
Research And Development Costs Capitalized
Capitalized R&D costs
Total revenues
Revenue
License and collaboration agreement revenues
Long-term purchase commitment, description
Long-Term Purchase Commitment, Description
General and Administrative Expense [Abstract]
General and administrative expenses:
Lessee, Operating Lease, Liability, to be Paid, Year Four
2029
Class of Stock
Class of Stock [Domain]
Computer and office equipment.
Computer And Office Equipment [Member]
Computer and Office Equipment [Member]
Commercial Paper [Member]
Commercial Paper [Member]
Share-Based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Period for Recognition
Unrecognized cost expected to be recognized over a weighted average period
Exercise price, granted
Share Based Compensation Arrangements By Share Based Payment Award Options Grants In Period Exercise Price
Share-based compensation arrangements by share-based payment award, options, grants in period exercise price.
Defined Contribution Plan, Maximum Annual Contributions Per Employee, Percent
Percentage of participants's annual salary
Entity Emerging Growth Company
Entity Emerging Growth Company
Available for sale investments number of positions.
Available for Sale Investments Number of Positions
Available for sale investments number of positions
Area of Land
Lease space
Additional collaboration revenue.
Additional Collaboration Revenue [Member]
Additional Collaboration Revenue [Member]
Tax Credit Carryforward, Name [Domain]
Tax Credit Carryforward, Name