aTyr Pharma Presents Positive Lung and Skin Findings with ATYR1923 in a Translational Animal Model at the Scleroderma Foundation National Patient Education Conference
“The data we are presenting tomorrow are part of our ongoing estate of translational animal models set to help inform and de-risk our upcoming clinical development of ATYR1923,” stated
Title: “ATYR1923 Ameliorates Dermal and Pulmonary Fibrosis in a Murine Model of Sclerodermatous
Chronic Graft vs. Host Disease”
- Data demonstrate ATYR1923 is efficacious in a murine model of sclerodermatous chronic graft versus host disease when administered weekly at only 0.4 mg/kg.
- ATYR1923 has robust activity when treatment was initiated at Day 7.
- ATYR1923 activity did not reach significance when treatment was initiated at Day 21.
- Data are compatible with aTyr’s hypothesis that ATYR1923 modulates immune responses and inflammation following tissue injury.
aTyr is a clinical-stage biotechnology company engaged in the discovery and clinical development of innovative medicines using its knowledge of tRNA synthetase biology. aTyr is focused on the therapeutic translation of the Resokine pathway, comprised of extracellular proteins derived from the histidyl tRNA synthetase (HARS) gene family. aTyr’s clinical stage ATYR1923 candidate augments the Resokine pathway and is designed to temper immune engagement in interstitial lung diseases. aTyr has built an intellectual property estate, to protect its pipeline, comprising over 250 issued patents or allowed patent applications that are owned or exclusively licensed, including over 300 potential protein compositions derived from tRNA synthetase genes. For more information, please visit http://www.atyrpharma.com.
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Sr. Director, Investor Relations
Source: aTyr Pharma, Inc.